UHS Paper of Pharmacology for M.B.B.S 2nd Professional 2011 (Questions)

Q.1

a)      What is receptor? Explain briefly the concept of Spare Receptors with examples.

b)      What is Drug Clearance? Give its role in the Drugs Elimination.

Q.2

a)      Give in Tabulated form the sites, structural features & post-receptors mechanism of muscarinic receptors- type1, 2 & 3.

b)      What is the pharmacological basis of Muscarinic agonists for the use in the eye & GIT problems?

Q.3

A 30 year old male has been prescribed a benzodiazepine drug for Generalized Anxiety Disorders (GAD) by a psychiatric.

a)      What will the advantages & disadvantages of Benzodiazepines?

b)      Which new group may be considered as drugs of first choice for GAD?

c)       Name at least four Selective Serotonin Reuptake Inhibitors (SSRIs). What is the reason of preferring SSRIs over other anti-depressants?

Q.4

a)      What is the pharmacokinetics of aspirins? Give the mechanism of action of aspirin for its pharmacological effects.

b)      Enumerate three TNF-α blocking agents. What are their important adverse effects?

Q.5

a)      A 40 year old male has been diagnoses as a patient of Congestive Cardiac Failure. Enumerate the different drug groups commonly used for heart failure to select proper management for him.

b)      Describe the Autonomic Actions of Cardiac Glycosides on the heart in CCF.

Q.6

a)      How Domperidone is useful in different clinical conditions?

b)      A 10 year old child is suffered from severe attack of asthma whenever he runs while playing with his friends. How can you manage him?

Q.7

a)      A 20 year old patient suffering from endocarditis caused by Methicillin Resistant Staphylococci. Which inhibitor of bacterial cell wall synthesis may be the first choice for the treatment? Enumerate its other use.

b)      Which is the drug of choice for one Corny-bacterial infection in a six year old child? Give important adverse effects of that drug.

Q.8

What is the mechanism of action & basis of resistance of the following?

a)      Isoniazid

b)      Ethambutol

c)       Chloroquine

Q.9

a)      A 45 year old patient is having a clack ulcer on his left leg infected due to some fungi. What various types of Azoles can be used against it?

b)      A 30 year old female is suffering from painful genital herpes lesion. What agents are useful to treat her infection?

Q.10

A 48 year old newly diagnosed diabetic patient is frequently showing post-meal rise in his blood glucose level.

a)      Which rapidly action insulin analogs can be used for more physiologic insulin replacement?

b)      What are their structural characteristics?

c)       Give their advantages to human insulin.